The effect of DDE and dieldrin and their parental substances (DDT and aldrin) on PGE2 and PGF2α release from bovine endometrial explants collected during 120 to 180 days of the gestational period

Dieldrin and DDE are environmental metabolites of the organochlorine pesticides aldrin DDT, respectively. During pregnancy, these chemicals can quickly infiltrate through placental barrier, accumulate in amniotic fluid fetus, act as endocrine disruptors (EDs). The aim this study was to investigate effect dieldrin their parental substances at concentrations 1 10 ng/ml on secretion PGE2 PGF2α from bovine endometrial explants (120-150 151-180 days pregnancy) after 24 hr incubation with EDs. mRNA expression COX2, PGES PGFS were measured. EDs did not affect (p>0.05) COX2 gene expression, but DDT decreased (p⟨0.05) 120-150 pregnancy. Depending dose, increased Aldrin all explants. In summary, disrupt by influencing PGFS.